Safe Cflags/Intel - Gentoo Linux Wiki

Warning: GCC 4.2 and above support -march=native, which automatically detects the optimum settings to use based on your processor. -march=native also detects and applies additional settings beyond -march specific to your CPU, (eg. -msse4). Unless you have a specific reason not to (e.g. distcc cross-compiling), you should probably be using -march=native rather than anything listed below.